Effect of accelerated iron ions on the retina

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577547· OSTI ID:6789849

Krebs, W; Krebs, I; Worgul, B V ^[1]

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1. Columbia Univ., New York, NY (USA)

The eyes of rats were exposed to doses of 0.1 and 2.5 Gy of 450-MeV/amu 56Fe particles (LET approximately 195 keV/microns). The beam axes were oriented perpendicular to the central retina of the animals. Retinas were harvested immediately (less than 10 min), 24 h, 15 days, 136 days, and 186 days after the experiment. The retinas of animals of equivalent ages were sampled at the same intervals. By Day 15, the spatial densities of the pigment epithelial, photoreceptor, and bipolar cells in retinas irradiated with 2.5 Gy were 15 to 20% lower than those of the controls. The cellular density of the pigment epithelium returned to the control level by Day 186 while photoreceptor and bipolar cell numbers remained depressed. One and fifteen days after irradiation, the choroidal vessels showed signs of radiation damage. Exposure to 0.1 Gy did not affect the cellular density within the retina at the interval examined (186 days). None of the retinas showed evidence of track-specific injury that could be interpreted as microlesions or tunnel lesions.

• OSTI ID: 6789849
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 123:2; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DOSES
ENERGY TRANSFER
EPITHELIUM
EVEN-EVEN NUCLEI
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
IRON 56
IRON ISOTOPES
ISOTOPES
LET
MAMMALS
NUCLEI
ORGANS
PIGMENTS
RADIATION DOSES
RADIATION EFFECTS
RATS
RETINA
RODENTS
SENSE ORGANS
STABLE ISOTOPES
TISSUES
VERTEBRATES