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Oral bioavailability of aged polychlorinated biphenyl residues contained in soil

Journal Article · · Bulletin of Environmental Contamination and Toxicology; (USA)
DOI:https://doi.org/10.1007/BF01701988· OSTI ID:6789089
; ;  [1]
  1. Department of Agriculture, Beltsville, MD (USA)
+ Show Author Affiliations

Bioavailability of toxic chemicals is a potentially important factor in determining the risk associated with soil contamination. Interest in bioavailability of chemicals recently increased because of such incidents as the Missouri and Seveso TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) episodes and the polybrominated biphenyl (PBB) episode in Michigan, which involved human and/or food animal exposure to accidentally contaminated soil. An inherent difficulty in interpreting bioavailability data obtained with environmental samples is that it is not possible to be certain of the extraction efficiency of the system used in the soil analyses. In this study, it was possible to utilize archival soil samples that had been treated with {sup 14}C-labelled polychlorobiphenyls (PCB) eight years previously. The primary purpose of this study was to compare the bioavailability of PCB in these soils with the bioavailability of PCB added to normal rat diets or corn oil. The secondary purpose was to compare dietary inclusion with gavage as a method of administration because gavage frequently was used in the previous studies.

OSTI ID:
6789089
Journal Information:
Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 43:5; ISSN 0007-4861; ISSN BECTA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL AVAILABILITY
CARBON 14 COMPOUNDS
CHLORINATED AROMATIC HYDROCARBONS
CORN OIL
ESTERS
HALOGENATED AROMATIC HYDROCARBONS
LABELLED COMPOUNDS
LIPIDS
MAMMALS
OILS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
RATS
RODENTS
SOILS
TRANSLOCATION
TRIGLYCERIDES
UPTAKE
VEGETABLE OILS
VERTEBRATES