The carcinogenic potency database: Analyses of 4000 chronic animal cancer experiments published in the general literature and by the U. S. National Cancer Institute/National Toxicology program
- Lawrence Berkeley Lab., CA (United States) Univ. of California, Berkeley, CA (United States)
- Univ. of California, Berkeley, CA (United States)
- Lawrence Berkeley, CA (United States)
The Carcinogenic Potency Database (CPDB) is an easily accessible, standardized resource of positive and negative long-term animal cancer tests. The CPDB has been published in four earlier papers that include results for approximately 4000 experiments on 1050 chemicals. This paper describes the CPDB: goals, inclusion criteria, fields of information, and published plot format. It also present an overview of our published papers using the CPDB. The CPDB as published in plot format readily permits comparisons of carcinogenic potency and many other aspects of cancer tests, including for each experiment the species and strain of tests animal, the route and duration of compound administration, dose level and other aspects of experimental protocol, histopathology and tumor incidence, TD[sub 50] (carcinogenic potency) and its statistical significance, dose response, author's opinion about carcinogenicity, and literature citation. A combined plot of all result from the four separate papers, which is ordered alphabetically by chemical, is available from L.S. Gold, in printed form or on computer tape or diskette. A computer readable (SAS) database is also available. The overview of papers includes descriptions of work on methods of estimating carcinogenic potency, reproducibility of results in near-replicate cancer tests, correlation in potency between species, ranking possible carcinogenic hazards, comparison of positivity and target organ in rats and mice, comparison of mutagens and nonmutagens, proportion of chemicals positive in animal tests, natural compared to synthetic chemicals, and mechanistic issues in interspecies extrapolations. 30 refs., 1 fig.
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 6788352
- Journal Information:
- Environmental Health Perspectives; (United States), Vol. 96; ISSN 0091-6765
- Country of Publication:
- United States
- Language:
- English
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The fifth plot of the Carcinogenic Potency Database: Results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989
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Related Subjects
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
CARCINOGENS
BIOLOGICAL EFFECTS
INFORMATION SYSTEMS
CARCINOGEN SCREENING
DATA BASE MANAGEMENT
MANAGEMENT
SCREENING
560300* - Chemicals Metabolism & Toxicology
990301 - Information Handling- Data Handling- (1992-)