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Chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1982

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.8667161· OSTI ID:5088607
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This paper is a chronological supplement to the earlier publication, A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays. The authors report here results of carcinogenesis bioassays published in Technical Reports of the National Cancer Institute/National Toxicology Program between July 1980 and December 1982, and the general literature between July 1981 and December 1982. This supplement includes results of 280 long-term, chronic experiments of 114 test compounds, and reports the same information about each experiment in the same plot format as the earlier paper: e.g., the species and strain of test animal, the route and duration of compound administration, dose level and other aspects of experimental protocol, histopathology and tumor incidence, TD/sub 50/ and its statistical significance, dose response, author's opinion about carcinogenicity, and literature reference. While a number of appendices are provided to facilitate use of this supplement, the authors have not duplicated here the material published earlier. Instead, they refer the reader to the earlier publications for a thorough description of the numerical index of carcinogenic potency (TD/sub 50/), a guide to the plot of the database, and a discussion of the sources of data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. For 44 of the 114 chemicals reported in this second plot, results of earlier experiments are also given in the first plot; since only 1981-1982 results are reported here, the first plot is required for these repeated compounds. In this paper they also give corrections for errors, that appeared in the earlier publication.
Research Organization:
Lawrence Berkeley Lab., CA
OSTI ID:
5088607
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 67; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
AZAARENES
AZINES
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGEN SCREENING
CARCINOGENS
CONDENSED AROMATICS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INFORMATION SYSTEMS
MAMMALS
MICE
MONKEYS
NEOPLASMS
NITRATES
NITRITES
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PRIMATES
PYRIDINES
QUINOLINES
RATS
RODENTS
SCREENING
VERTEBRATES