Toxicity of /sup 241/Am and /sup 241/Cm after administration at nine days of gestation in the rat

Journal Article · Wed Jan 01 00:00:00 EST 1975 · Radiat. Res.; (United States)

OSTI ID:6787238

Sikov, M R; Mahlum, D D

10 ..mu..Ci/kg body weight of plutonium has been found to be embryocidal, but not teratogenic, when administered to rats after 9 days of gestation. Previous studies suggest that this effect was primarily due to nuclide incorporated in the fetal membranes and, to a lesser extent, in the placenta. Other transuranic elements are distributed similarly to plutonium although there are specific differences. Americium-241 or curium-244 citrate, pH 4.0--4.5, were intravenously injected into rats after 9 days of gestation to compare their prenatal toxicities with that of plutonium and to define their deposition in the fetoplacental unit (FPU) relative to other transuranic elements. In rats killed after 20 days of gestation, it was found that neither nuclide increased the incidence of prenatal mortality or malformations, even at doses up to and including 60 ..mu..Ci/kg. In rats killed at 1, 3 or 5 days postinjection, a marked avidity of the livers of the dams for /sup 241/Am and /sup 244/Cm was noted. This presumably led to a shortened half-time in blood and to lower concentrations in the FPU than was observed with most of the transuranic elements studied to date. It thus appears that /sup 241/Am and /sup 244/Cm are less embryocidal than plutonium and that this is a result of lower concentrations in the placenta and fetal membranes.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 6787238
• Journal Information: Radiat. Res.; (United States), Vol. 62
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMERICIUM 241
BIOLOGICAL RADIATION EFFECTS
CURIUM 244
PLUTONIUM
PRENATAL IRRADIATION
COMPARATIVE EVALUATIONS
EMBRYOS
FETUSES
INTRAVENOUS INJECTION
LETHAL DOSES
LIVER
MALFORMATIONS
MORTALITY
PLACENTA
PREGNANCY
RATS
TIME DEPENDENCE
TOXICITY
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ACTINIDES
ALPHA DECAY RADIOISOTOPES
AMERICIUM ISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CURIUM ISOTOPES
DIGESTIVE SYSTEM
DISEASES
DOSES
ELEMENTS
EVEN-EVEN NUCLEI
FETAL MEMBRANES
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
IRRADIATION
ISOTOPES
MAMMALS
MEMBRANES
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
TRANSURANIUM ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
560162 - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells