Prostaglandin synthetase dependent benzo(a)pyrene oxidation: products of the oxidation and inhibition of their formation by antioxidants
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
The products of the arachidonic acid dependent oxidation of benzo(a)pyrene by enzyme preparations from sheep seminal vesicles are the 1,6-, 3,6-, and 6,12- quinones. The metabolites were identified by high performance liquid chromatography and visible spectroscopy. The amount of benzo(a)pyrene converted to quinones by a Tween 20 solubilized preparation during a 15 min period is ..mu..M/mg protein. The relative yields of the individual quinones are 1,6 - 25%, 3,6 - 30%, and 6,12 - 45%. Arachidonate dependent benzo(a)pyrene oxidation is strongly inhibited by butylated hydroxyanisole, vitamin E, and diethyldithiocarbamate and moderately inhibited by butylated hydroxytoluene and vitamin C. Epinephrine and lipoic acid are also inhibitors.
- Research Organization:
- Wayne State Univ., Detroit
- OSTI ID:
- 6784988
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 79:2; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550500 -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
ANISOLE
ARACHIDONIC ACID
AROMATICS
ASCORBIC ACID
BENZOPYRENE
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL REACTIONS
CHROMATOGRAPHY
CONDENSED AROMATICS
CRESOLS
DEDTC
DISULFIDES
DRUGS
ENZYMES
ETHERS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
INHIBITION
LIPOTROPIC FACTORS
METABOLISM
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
PHENOLS
PROSTAGLANDINS
SEPARATION PROCESSES
SPECTROSCOPY
STEROID HORMONES
SYMPATHOMIMETICS
THIOCTIC ACID
VITAMIN E
VITAMINS
550500 -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
ANISOLE
ARACHIDONIC ACID
AROMATICS
ASCORBIC ACID
BENZOPYRENE
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL REACTIONS
CHROMATOGRAPHY
CONDENSED AROMATICS
CRESOLS
DEDTC
DISULFIDES
DRUGS
ENZYMES
ETHERS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
INHIBITION
LIPOTROPIC FACTORS
METABOLISM
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
PHENOLS
PROSTAGLANDINS
SEPARATION PROCESSES
SPECTROSCOPY
STEROID HORMONES
SYMPATHOMIMETICS
THIOCTIC ACID
VITAMIN E
VITAMINS