Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Correlation of survival with the restoration of DNA structure in x-irradiated L5178Y S/S cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575346· OSTI ID:6784735
; ;
After exponentially growing populations of the radiosensitive S/S variant of the L5178Y murine leukemic lymphoblast were exposed to low doses of x rays (less than or equal to 100 rad), the majority of the radiation-induced strand breaks in the DNA appeared to be rejoined within 5 to 10 hr. Subsequently, the DNA resolved slowly into a component that finally degraded into small pieces and a component that regained the size of the DNA in unirradiated cells long after irradiation (days). The fraction of the latter component correlated directly with the fraction of surviving cells. A similar correlation was found when semisynchronous populations of the S/S variant were x-irradiated ( less than or equal to 200 rad) during the radioresistant phase of the cell cycle.
Research Organization:
Colorado State Univ., Fort Collins
OSTI ID:
6784735
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:3; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Repair of double-strand DNA breaks correlates with radiosensitivity of L5178Y-S and L5178Y-R cells
Journal Article · Thu Oct 01 00:00:00 EDT 1987 · Radiat. Res.; (United States) · OSTI ID:5849002
Deficient repair and degradation of DNA in X-irradiated L5178Y S/S cells: cell-cycle and temperature dependence
Journal Article · Wed Aug 01 00:00:00 EDT 1979 · Radiat. Res.; (United States) · OSTI ID:5705929
Deficient repair and degradation of DNA in L5178Y S/S cells
Journal Article · Wed Aug 01 00:00:00 EDT 1979 · Radiat. Res.; (United States) · OSTI ID:5638361

Related Subjects

560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CULTURES
CELL CYCLE
CONNECTIVE TISSUE CELLS
DATA
DISEASES
DNA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
HEMIC DISEASES
INFORMATION
IONIZING RADIATIONS
LEUKEMIA
LEUKOCYTES
LYMPHOCYTES
MATERIALS
NEOPLASMS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
STRAND BREAKS
SURVIVAL CURVES
X RADIATION