16 alpha-(/sup 77/Br)bromoestradiol: dosimetry and preliminary clinical studies

Journal Article · Sat May 01 00:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6783501

McElvany, K D; Katzenellenbogen, J A; Shafer, K E; Siegel, B A; Senderoff, S G; Welch, M J

An estrogen-receptor-binding radiopharmaceutical, 16 alpha-(/sup 77/Br)bromoestradiol-17 beta, has been used successfully at high specific activity to image carcinogen-induced mammary tumors in rats and in preliminary studies to image breast tumors in patients. The biodistribution of the labeled estrogen in rats and its clearance in a monkey were used to estimate the radiation absorbed doses to a human resulting from administration of the radiopharmaceutical. Preliminary imaging studies in patients with mammary carcinoma show promising results and warrant further development of radiolabeled estrogens, particularly those carrying positron emitters that could permit positron emission tomography--for example /sup 75/Br or /sup 18/F.

• Research Organization: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
• OSTI ID: 6783501
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE 77
BROMINE ISOTOPES
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ESTRADIOL
ESTRANES
ESTROGENS
GLANDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAMMARY GLANDS
MINUTES LIVING RADIOISOTOPES
MONKEYS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIATION DOSES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RECEPTORS
RODENTS
STEROID HORMONES
STEROIDS
TISSUE DISTRIBUTION
TOMOGRAPHY
USES
VERTEBRATES