In vivo comparison of 16 alpha(/sup 77/Br)bromoestradiol-17 beta and 16 alpha-(/sup 125/I)iodoestradiol-17 beta
An in vivo comparison of two estrogen-receptor-binding radiopharmaceuticals of high specific activity, 16 alpha-(/sup 77/Br)bromoestradiol-17 beta and 16 alpha-(/sup 125/I)iodoestradiol-17 beta, has been carried out in immature female rats. The iodoestradiol has slightly higher uterine uptake at 1 hr after injection, whereas the brominated analog has significantly enhanced uptake at later times. The similar behavior of the two compounds in vivo suggests that estradiol labeled with /sup 123/I, /sup 77/Br, or /sup 75/Br could be used interchangeably for the imaging of breast tumors containing estrogen receptors. In addition, coinjection of 16 alpha-(/sup 125/I)iodoestradiol as an internal standard has been shown to be useful for comparison of different radiohalogenated estrogens.
- Research Organization:
- Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
- OSTI ID:
- 6816762
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
16 alpha-(/sup 77/Br)bromo-11 beta-methoxyestradiol-17 beta: a gamma-emitting estrogen imaging agent with high uptake and retention by target organs
16. cap alpha. -(/sup 77/Br)bromoestradiol-17. beta. : a high specific-activity, gamma-emitting tracer with uptake in rat uterus and induced mammary tumors
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE 75
BROMINE 77
BROMINE ISOTOPES
CARCINOMAS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
GLANDS
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IN VIVO
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAMMARY GLANDS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RECEPTORS
RODENTS
STEROID HORMONES
STEROIDS
UPTAKE
USES
UTERUS
VERTEBRATES