T1-201 per rectum: A noninvasive method for evaluating portosystemic shunt

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6781428

Verdickt, X; Reding, P; Tshiamala, P; Ham, H R

Portosystemic shunt is one of the most important complications of liver cirrhosis. Unfortunately, current methods for detecting and quantifying this shunt are either non-specific or associated with significant morbidity. The aim of this work was to evaluate the clinical value of a new non-traumatic method which consisted of administrating T1-201 per rectum and monitoring the absorbed activity using a camera and a computer system. The method assumes that in the absence of portosystemic shunt, most of the absorbed activity will be fixed in the liver while in the presence of this shunt, some of the activity will be fixed in the myocardium. The ratio of heart to liver activity can therefore be used to evaluate the importance of the portosystemic shunt. 34 subjects have been studied. The ratio of heart to liver activity at the 25th minute after the tracer administration is higher in patients with liver cirrhosis (n=22, m=.9, s.d.=.37) than in patients with steatosis (n=10, m=.28, s.d.=.03). In two healthy subjects investigated the H/L ratio was .27 and .30. The reproducibility of the test was evaluated in 8 subjects and showed a good reproducibility (mean of difference =.03, range=.01 to .07). Patients with esophageal varices had always a high H/L ratio while some patients with liver cirrhosis without esophageal varices had also high H/L ratio, probably due to the presence of intrahepatic shunt. The authors' results showed the value of this new non-traumatic test for detecting and quantifying extra- as well as intrahepatic portosystematic shunt.

• Research Organization: Dept. Radioisotopes and Gastroenterology, St. Peter Hospital, Free Univ. of Brussels
• OSTI ID: 6781428
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ESOPHAGUS
GASTROINTESTINAL TRACT
GLANDS
HEART
HEAVY NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LARGE INTESTINE
LIVER
LIVER CIRRHOSIS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PORTAL SYSTEM
RADIOISOTOPES
RECTUM
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TRACER TECHNIQUES
UPTAKE
USES
VASCULAR DISEASES
VEINS