A noninvasive method for evaluating portal circulation by administration of /sup 201/Tl per rectum

Journal Article · Mon Nov 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:6531711

Tonami, N; Nakajima, K; Hisada, K; Tanaka, N; Kobayashi, K

A new method for evaluating portal systemic circulation by administration of /sup 201/Tl per rectum was performed in 13 control subjects and in 65 patients with various liver diseases. In normal controls, the liver was visualized on the 0--5-min image whereas the images of other organs such as the heart, spleen, and lungs were very poor. In patients with liver cirrhosis associated with portal-systemic shunt, and in many other patients with hepatocellular damage, the liver was not so clearly visualized, whereas radioactivity in other organs, especially the heart, became evident. The heart-to-liver uptake ratio at 20 min after administration (H/L ratio) was significantly higher in liver cirrhosis than in normals and patients with chronic hepatitis (p less than 0.001). The patients with esophageal varices showed a significantly higher H/L ratio compared with that in cirrhotic patients without esophageal varices (p less than 0.001). The H/L ratio also showed a significant difference (p less than 0.01) between Stage 1 and Stage 3 esophageal varices. Since there were many other patients with hepatocellular damage who had high H/L ratios similar to those in liver cirrhosis, the effect that hepatocellular damage has on the liver uptake of /sup 201/Tl is also considered. Our present data suggest that this noninvasive method seems to be useful in evaluating portal-to-systemic shunting.

• Research Organization: Kanazawa University, Japan
• OSTI ID: 6531711
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HEAVY NUCLEI
HEPATITIS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER
LIVER CIRRHOSIS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
PATIENTS
PORTAL SYSTEM
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
USES
VEINS