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In vitro radiosensitivity of six human cell lines. II. Relation to the RBE of 50-MeV neutrons

Journal Article · · Radiat. Res.; (United States)
OSTI ID:6778261
 [1]; ; ; ; ;
  1. Institut Gustave-Roussy, Villejuif, France
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The sensitivities of six human cell lines to 50-MeV neutrons were studied using the colony-forming assay in vitro. Two models were used to fit the survival curves: the linear-quadratic (L-Q) model and the single-hit multitarget model with initial slope. The quality of the resulting fits was compared with two analytical procedures. One measured the accuracy of the fits, and the other led to an estimation of the validity of the parameters obtained. The L-Q model responded satisfactorily to these two procedures and could be used to demonstrate that: (1) neutron action can be explained adequately by the same model of cell killing that applies to ..gamma.. rays; (2) neutron survival curves were different for each cell line; (3) the neutron survival parameters change differently for each line in comparison to ..gamma..-ray survival parameters; and (4) the biological parameters determining the differences among cell lines are of utmost importance in determining radiosensitivities at high and low linear energy transfers. Relative biological effectiveness varied from 3 to 1.2.
OSTI ID:
6778261
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 90:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560115 -- Radiation Effects on Biochemicals-- In Man-- (-1987)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CESIUM 137
CESIUM ISOTOPES
DOSE RATES
ELEMENTARY PARTICLES
FERMIONS
HADRONS
ISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY
RBE
SURVIVAL CURVES
TUMOR CELLS
YEARS LIVING RADIOISOTOPES