In vitro radiosensitivity of six human cell lines. A comparative study with different statistical models

Journal Article · Thu May 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575381· OSTI ID:5157722

Fertil, B; Deschavanne, P J; Lachet, B; Malaise, E P

The intrinsic radiosensitivity of human cell lines (five tumor and one nontransformed fibroblastic) was studied in vitro. The survival curves were fitted by the single-hit multitarget, the two-hit multitarget, the single-hit multitarget with initial slope, and the quadratic models. The accuracy of the experimental results permitted evaluation of the various fittings. Both a statistical test (comparison of variances left unexplained by the four models) and a biological consideration (check for independence of the fitted parameters vis-a-vis the portion of the survival curve in question) were carried out. The quadratic model came out best with each of them. It described the low-dose effects satisfactorily, revealing a single-hit lethal component. This finding and the fact that the six survival curves displayed a continuous curvature ruled out the adoption of the target models as well as the widely used linear regression. As calculated by the quadratic model, the parameters of the six cell lines lead to the following conclusions: (a) the intrinsic radiosensitivity varies greatly among the different cell lines; (b) the interpretation of the fibroblast survival curve is not basically different from that of the tumor cell lines; and (c) the radiosensitivity of these human cell lines is comparable to that of other mammalian cell lines.

• Research Organization: Institut de Radiobiologie Clinique, Villejuif, France
• OSTI ID: 5157722
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CESIUM 137
CESIUM ISOTOPES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAMMA RADIATION
IN VITRO
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LOW DOSE IRRADIATION
MATHEMATICAL MODELS
NUCLEI
ODD-EVEN NUCLEI
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
SOMATIC CELLS
SURVIVAL CURVES
TUMOR CELLS
YEARS LIVING RADIOISOTOPES