Action spectrum for retinal injury from near-ultraviolet radiation in the aphakic monkey

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Am. J. Ophthalmol.; (United States)

DOI:https://doi.org/10.1016/0002-9394(82)90529-3· OSTI ID:6777726

Ham, Jr, W T; Mueller, H A; Ruffolo, Jr, J J; Guerry, D; Guerry, R K

We found that the action spectrum for retinal damage (determined by the fundus photographic appearance of a minimal lesion immediately after exposure) extends into the near-ultraviolet by exposing three aphakic eyes from rhesus monkeys to 405-, 380-, 350-, and 320-nm wavelengths produced by a 2,500-W xenon lamp equipped with quartz optics and 10-nm interference filters. Exposure times were 100 and 1,000 seconds and the spot diameter on the retina was 500 micrometers. The retina was six times more sensitive to 350- and 325-nm wavelengths than to blue light (441 nm). Both ophthalmoscopic and histologic data showed that near-ultraviolet lesions differed in important respects from blue-light lesions. Near-ultraviolet produced irreparable damage to rod and cone photoreceptors.

• Research Organization: Department of Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond
• OSTI ID: 6777726
• Journal Information: Am. J. Ophthalmol.; (United States), Journal Name: Am. J. Ophthalmol.; (United States) Vol. 93:3; ISSN AJOPA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
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560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DOSES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
MACACUS
MAMMALS
MEDICINE
MONKEYS
OPHTHALMOLOGY
ORGANS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RECEPTORS
RETINA
SENSE ORGANS
SENSITIVITY
TIME DEPENDENCE
ULTRAVIOLET RADIATION
VERTEBRATES