Age dependent retention of /sup 212/Pb in the skeleton following /sup 224/Ra uptake

Conference · Wed Jan 01 04:00:00 EST 1986

OSTI ID:6775658

Schlenker, R A

The purpose of this paper is to summarize unpublished analyses of the /sup 212/Pb retention data and to provide numerical estimates of the variation of /sup 212/Pb//sup 224/Ra with age in humans. The principal conclusions are that skeletal /sup 212/Pb//sup 224/Ra increases with time after injection, increases with increasing body weight among species, increases with decreasing bone surface-to-volume ratio, and most likely increases with age in humans. These results will have practical implications to the dosimetry of /sup 224/Ra and its daughter products in humans. In studies of cancer induction by the /sup 224/Ra decay series, subjects have been as young as one year at injection, and a large fraction of the tumors have appeared in subjects exposed as juveniles. The chance that dosimetric data will become available from observations on humans is very small. Interspecies extrapolations such as the one summarized here will be necessary to adjust and refine dosimetry for humans. 13 refs., 6 tabs.

• Research Organization: Argonne National Lab., IL (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6775658
• Report Number(s): CONF-861123-7; ON: DE87004694
• Country of Publication: United States
• Language: English

Related Subjects

560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOGS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
ISOTOPES
LEAD 210
LEAD ISOTOPES
MAMMALS
MAN
MICE
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
RADIUM 224
RADIUM ISOTOPES
RATS
RODENTS
SKELETON
SPECIES DIVERSITY
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES