Orally active alpha-ketohydroxypyridine iron chelators: studies in mice
Journal Article
·
· Mol. Pharmacol.; (United States)
OSTI ID:6775607
Several N-substituted 3-hydroxypyrid-2-one and N-substituted 2-methyl-3-hydroxypyrid-4-one chelators were screened for /sup 59/Fe removal using iron-overloaded mice labeled with /sup 59/Fe. The most effectice chelators were found to be the N-methyl, N-ethyl, and N-propyl derivatives of 2-methyl-3-hydroxypyrid-4-one. When the above three chelators were administered intragastrically or intraperitoneally (200 mg/kg) to mice, they caused equivalent /sup 59/Fe excretions to intraperitoneal desferrioxamine (200 mg/kg). These results increase the prospects for the use of the alpha-ketohydroxypyridine chelators in the treatment of iron overload.
- Research Organization:
- Univ. College London, England
- OSTI ID:
- 6775607
- Journal Information:
- Mol. Pharmacol.; (United States), Journal Name: Mol. Pharmacol.; (United States) Vol. 6; ISSN MOPMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBOHYDRATES
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
GLOBULINS
GLUCOPROTEINS
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPES
LACTOFERRIN
MAMMALS
METALLOPROTEINS
MICE
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
REMOVAL
RODENTS
SACCHARIDES
VERTEBRATES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBOHYDRATES
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
GLOBULINS
GLUCOPROTEINS
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPES
LACTOFERRIN
MAMMALS
METALLOPROTEINS
MICE
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
REMOVAL
RODENTS
SACCHARIDES
VERTEBRATES