Radiation necrosis of the mandible: a 10 year study. Part I. Factors influencing the onset of necrosis

Journal Article · Thu May 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90380-6· OSTI ID:6773240

Murray, C G; Herson, J; Daly, T E; Zimmerman, S

Of 404 patients who were irradiated for cancer in the oral region between 1971 and 1975, 19.1% developed radiation necrosis of the mandible. Three main effects, anatomic tumor site, tumor dose, and dental status, were found to have a statistically significant effect on incidence of necrosis. Necrosis was also found to occur more frequently in association with an implant than with treatment administered by an external radiation source alone. The T-stage of the tumor did not appear to affect the incidence of necrosis. Necrosis incidence was also studied over the two time periods: 1966 to 1969 (study I) and 1971 to 1975 (study II). Differences between the two periods were found in the primary etiological groupings. Necrosis attributed to spontaneous or unknown cause increased in the second study, while that associated with dental extractions before irradiation decreased. Fewer teeth were extracted before radiation therapy in study II than in study I. Less necrosis followed mandibular surgery for recurrent disease in study II than study I.

• Research Organization: Univ. of Texas System Cancer Center, Houston
• OSTI ID: 6773240
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:5; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
INJURIES
INTERNAL IRRADIATION
IRRADIATION
JAW
LOCAL RADIATION EFFECTS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
OSTEORADIONECROSIS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SKULL
TEETH
THERAPY