The pulmonary response of white and black adults to six concentrations of ozone

Journal Article · Thu Apr 01 00:00:00 EST 1993 · American Review of Respiratory Disease; (United States)

DOI:https://doi.org/10.1164/ajrccm/147.4.804· OSTI ID:6773183

Seal, E Jr; McDonnell, W F; House, D E; Salaam, S A; Dewitt, P J; Butler, S O; Green, J; Raggio, L ^[1]

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1. Environmental Protection Agency, Chapel Hill, NC (United States)

Many early studies of respiratory responsiveness to ozone (O3) were done on healthy, young, white males. The purpose of this study was to determine whether gender or race differences in O3 response exist among white and black, males and females, and to develop concentration-response curves for each of the gender-race groups. Three hundred seventy-two subjects (n > 90 in each gender-race group), ages 18 to 35 yr, were exposed once for 2.33 h to 0.0 (purified air), 0.12, 0.18, 0.24, 0.30, or 0.40 ppm O3. Each exposure was preceded by baseline pulmonary function tests and a symptom questionnaire. The first 2 h of exposure included alternating 15-min periods of rest and exercise on a motorized treadmill producing a minute ventilation (VE) of 25 L/min/m2 body surface area (BSA). After exposure, subjects completed a set of pulmonary function tests and a symptom questionnaire. Lung function and symptom responses were expressed as percent change from baseline and analyzed using a nonparametric two factor analysis of variance. Three primary variables were analyzed: FEV1, specific airway resistance (SRaw), and cough. Statistical analysis demonstrated no significant differences in response to O3 among the individual gender-race groups. For the group as a whole, changes in the variables FEV1, SRaw, and cough were first noted at 0.12, 0.18, and 0.18 ppm O3, respectively. Adjusted for exercise difference, concentration-response curves for FEV1 and cough among white males were consistent with previous reports (1).

• OSTI ID: 6773183
• Journal Information: American Review of Respiratory Disease; (United States), Vol. 147:4; ISSN 0003-0805
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BLACK AMERICANS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
RESPIRATION
SEX DEPENDENCE
FEMALES
MALES
OZONE
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ADULTS
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VOLUME
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EVALUATION
HUMAN POPULATIONS
MINORITY GROUPS
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