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Effects of ozone and nitrogen dioxide on pulmonary function in healthy and in asthmatic adolescents

Journal Article · · Am. Rev. Respir. Dis.; (United States)
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The aim of this project was to investigate whether well-characterized asthmatic adolescent subjects were more sensitive to the inhaled effects of oxidant pollutants than were well-characterized healthy adolescent subjects. Ten healthy and 10 asthmatic subjects inhaled via a mouth-piece 0.12 or 0.18 ppm of ozone (O/sub 3/) or nitrogen dioxide (NO/sub 2/) or clean air for 30 min at rest followed by 10 min during moderate exercise (32.5 L/min) on a treadmill. The following pulmonary functional values were measured before and after exposure: peak flow, total respiratory resistance (RT), maximal flow at 50 and 75% of expired VC, and FEV1. After exercise exposure to 0.18 ppm O3, statistically significant increases were seen in RT in asthmatic and healthy adolescent subjects. No consistent changes were seen in either group after NO/sub 2/ exposure. Also, no significant differences in response to oxidant pollutants between the 2 groups could be demonstrated. It was concluded that neither group was consistently sensitive to these pollutants.

Research Organization:
Univ. of Washington, Seattle
OSTI ID:
5833612
Journal Information:
Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 136:5; ISSN ARDSB
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AGE GROUPS
AIR POLLUTION
ASTHMA
BODY
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EXERCISE
INHALATION
INTAKE
LUNGS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PATHOGENESIS
POLLUTION
RESPIRATION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
TOXICITY