Biocompatibility of clinically applied hydroxylapatite ceramic

Journal Article · Thu Feb 01 04:00:00 EST 1990 · Annals of Otology, Rhinology, and Laryngology, Supplement; (USA)

OSTI ID:6772872

van Blitterswijk, C A; Grote, J J ^[1]

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1. University Hospital Leiden (Netherland)

The biocompatibility of 11 porous canal wall prostheses and 4 dense incus prostheses, both types made of hydroxylapatite, was studied by light microscopy, scanning electron microscopy, transmission electron microscopy, and x-ray microanalysis. The duration of implantation varied between 4 and 40 months, and the 15 retrieved implants constitute 4% of the 375 clinically applied hydroxylapatite prostheses involved in this study. With respect to integration characteristics, coverage by epithelium and fibrous tissue, and biodegradation, the performance of clinically applied hydroxylapatite generally resembled that seen in animal experiments. However, the reactions during chronic infection in the human ear were more severe than those in experimentally induced acute infections in the rat middle ear. One of the canal wall prostheses showed trace element accumulation in the cytoplasm of phagocytes.

• OSTI ID: 6772872
• Journal Information: Annals of Otology, Rhinology, and Laryngology, Supplement; (USA), Journal Name: Annals of Otology, Rhinology, and Laryngology, Supplement; (USA) Vol. 144; ISSN 0096-8056; ISSN XZ001
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
AUDITORY ORGANS
BODY
CHEMICAL ANALYSIS
DISEASES
ELECTRON MICROPROBE ANALYSIS
ELECTRON MICROSCOPY
EPITHELIUM
MEDICAL SUPPLIES
MICROANALYSIS
MICROSCOPY
ORGANS
PROSTHESES
SCANNING ELECTRON MICROSCOPY
SENSE ORGANS
SENSE ORGANS DISEASES
SURFACE PROPERTIES
THERAPY
TISSUES
TRANSMISSION ELECTRON MICROSCOPY