Particle shedding and migration from silicone genitourinary prosthetic devices
- Department of Urology, Mayo Clinic, Rochester, MN (USA)
Of 26 patients undergoing revision of genitourinary prostheses the surrounding reactive fibrous capsule was biopsied in 25 and the draining lymph nodes also were biopsied in 4. The prostheses included 16 inflatable and 14 flexible penile devices, and 10 artificial urinary sphincters. Tissue was examined by light and transmission electron microscopy. X-ray microanalysis was done on intracellular and extracellular foreign material from each specimen. Silicone was found in 18 of the 25 periprosthetic specimens and in all 4 lymph nodes. Foreign body granulomas were identified in 14 of these 29 specimens. Examination of new and explanted versions of each prosthesis by scanning electron microscopy revealed free particles of silicone or silicates on the surface of most devices. Pitting and microfissuring were seen on a few of the new devices and on nearly all of the used ones. Thus, genitourinary prostheses shed silicone particles that can be found in the fibrous capsule and draining lymph nodes.
- OSTI ID:
- 5449929
- Journal Information:
- Journal of Urology; (United States), Vol. 146:2; ISSN 0022-5347
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL TISSUES
ELECTRON MICROPROBE ANALYSIS
URINARY TRACT
PROSTHESES
BIOPSY
FIBROSIS
GRANULOMAS
LYMPH NODES
PATIENTS
SCANNING ELECTRON MICROSCOPY
SILICONES
TRANSMISSION ELECTRON MICROSCOPY
BODY
CHEMICAL ANALYSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON MICROSCOPY
LYMPHATIC SYSTEM
MEDICAL SUPPLIES
MICROANALYSIS
MICROSCOPY
NEOPLASMS
NONDESTRUCTIVE ANALYSIS
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POLYMERS
SILOXANES
TISSUES
550602* - Medicine- External Radiation in Diagnostics- (1980-)