Atrial natriuretic peptide increases resistance to venous return in rats

Journal Article · Fri May 01 00:00:00 EDT 1987 · Am. J. Physiol.; (United States)

OSTI ID:6766348

Chien, Y W; Frohlich, E D; Trippodo, N C

To examine mechanisms by which administration of atrial natriuretic peptide (ANP) decreases venous return, the authors compared the hemodynamic effects of ANP furosemide (FU), and hexamethonium (HEX) with those of vehicle (VE) in anesthetized rats. Compared with VE, ANP reduced mean arterial pressure, central venous pressure, and cardiac index and increased calculated resistance to venous return. /sup 141/Ce-labeled microspheres were used to determine cardiac output. Mean circulatory filling pressure, distribution of blood flow between splanchnic organs and skeletal muscles, and total peripheral resistance remained unchanged. FU increased urine output similar to that of ANP, yet produced no hemodynamic changes, dissociating diuresis, and decreased cardiac output. HEX lowered arterial pressure through a reduction in total peripheral resistance without altering cardiac output or resistance to venous return. The results confirm previous findings that ANP decreases cardiac output through a reduction in venous return and suggest that this results partly from increased resistance to venous return and not from venodilation or distribution of blood flow.

• Research Organization: Alton Ochsner Medical Foundation, New Orleans, LA (USA)
• OSTI ID: 6766348
• Journal Information: Am. J. Physiol.; (United States), Vol. 252:5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
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CERIUM 141
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HEART
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ORGANS
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551001* - Physiological Systems- Tracer Techniques