Development of an aerosol dispersion test to detect early changes in lung function

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668891379891· OSTI ID:6765449

McCawley, M; Lippmann, M

The dispersion of a 0.5 micron aerosol bolus during tidal breathing differs significantly (p less than 0.0001) between a group of smokers (with approximately 20 pack-years average exposure) and a comparable group of nonsmokers. Their mean differences in standard respiratory function indexes from spirometry (forced vital capacity (FVC), forced expiratory volume in one second (FEV1), mean forced expiratory flow during the middle half of the FVC (FEF25-75)) were smaller and not statistically significant. The test is simple to perform and may be done as quickly as spirometry but without using a forced exhalation. Comparison of the coefficients of variation for the dispersion test and FEV1 indicate that the aerosol dispersion test may be useful in epidemiologic investigations either by reducing the required population size or increasing the level of confidence.

• Research Organization: New York Univ. Medical Center, NY (USA)
• OSTI ID: 6765449
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 49:7; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
BODY
COLLOIDS
DISPERSIONS
DYNAMIC FUNCTION STUDIES
ENVIRONMENTAL EXPOSURE
INHALATION
INTAKE
LUNGS
MATHEMATICS
ORGANS
PARTICLE SIZE
POLLUTION
REGRESSION ANALYSIS
RESIDUES
RESPIRATORY SYSTEM
SIZE
SMOKES
SOLS
STATISTICS
TOBACCO SMOKES