Effect of ozone exposure on the dispersion of inhaled aerosol boluses in healthy human subjects

Technical Report · Thu Dec 06 04:00:00 EST 1990

OSTI ID:5185843

Keefe, M J; Bennett, W D; Dewitt, P; Seal, E; Strong, A A

Acute exposure of humans to low levels of ozone are known to cause decreases FVC and increases sRaw. These alterations in lung function do not, however, elucidate the potential for acute small airways responses. In the study the authors employed a test of aerosol dispersion to examine the potential effects of ozone on small airways in humans. Twenty-two healthy non-smoking male volunteers were exposed to 0.4 ppm ozone for one hour while exercising at 20 l/min/m{sup 2} (BSA). Prior to and immediately following exposure, tests of spirometry (FVC, FEV1, and FEF25-75) and plethysmography (Raw and sRaw) were performed. Subjects also performed an aerosol dispersion test before and after exposure. Each test involved a subject inhaling five to seven breaths of a 300 ml bolus of a 0.5 micrometers triphenyl phosphate (TPP) aerosol injected into a 2 liters tidal volume. The bolus was injected into the tidal breath at three different depths: at depth A the bolus was injected after 1.6 liters of clean air was inhaled from FRC; at depth B after 1.2 liters; and at depth C after 1.2 liters but with inhalation beginning from RV. The primary measure of bolus dispersion was the expired half-width (HW).

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
• OSTI ID: 5185843
• Report Number(s): PB-91-231266/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AEROSOLS
AIR POLLUTION
ANIMALS
BODY
COLLOIDS
DISPERSIONS
EXERCISE
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
ORGANS
OZONE
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SENSITIVITY
SOLS
TOXICITY
VERTEBRATES