/sup 111/In-platelet survival kinetics: Tropolone vs oxine method

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760985

Vallabhajosula, S; Machac, J; Lipszyc, H; Badimon, L; Goldsmith, S J; Fuster, V

/sup 111/In-tropolone (In-tr) is being evaluated because of its greater affinity for platelets in plasma than /sup 111/In-oxine (In-ox). Platelets separated from a 50 ml blood sample were labeled with In-tr in 2 ml autologous plasma and In-ox in 4 ml ACD-saline. 10 blood samples starting at 1 hr were obtained over a 8 day period. Platelet survival was calculated based on linear, exponential and multi hit analysis. The life-span of platelets measured by tropolone and oxine methods were compared in the same 8 normal human subjects and were performed 2 months apart. With In-tr, the platelet recovery is higher at 1 hr and throughout the 8-days and the gamma camera images showed less uptake in liver and spleen than In-ox. In addition, linear model is the best fit (63%) with a life-span equal or slightly longer than In-ox. Linear model is the best fit (100%) with In-ox and the multiple hit analysis also showed significantly higher number of hits (34) compared to In-tr (15). There is no correlation between in vivo recovery of /sup 111/In-platelets (tropolone or oxine) and the platelet life span. These results show that even though the platelet life span is not significantly altered by labeling method, they are better preserved in circulation when labeled with In-tr.

• Research Organization: Mt. Sinai Medical Center, New York, NY
• OSTI ID: 6760985
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CHEMICAL PREPARATION
CHEMICAL REACTION KINETICS
CORRELATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
FUNCTIONS
GLANDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LABELLING
LIVER
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
REACTION KINETICS
RETENTION FUNCTIONS
SPLEEN
SYNTHESIS
TISSUE DISTRIBUTION
UPTAKE