/sup 111/In-platelet survival kinetics: Tropolone vs oxine method
/sup 111/In-tropolone (In-tr) is being evaluated because of its greater affinity for platelets in plasma than /sup 111/In-oxine (In-ox). Platelets separated from a 50 ml blood sample were labeled with In-tr in 2 ml autologous plasma and In-ox in 4 ml ACD-saline. 10 blood samples starting at 1 hr were obtained over a 8 day period. Platelet survival was calculated based on linear, exponential and multi hit analysis. The life-span of platelets measured by tropolone and oxine methods were compared in the same 8 normal human subjects and were performed 2 months apart. With In-tr, the platelet recovery is higher at 1 hr and throughout the 8-days and the gamma camera images showed less uptake in liver and spleen than In-ox. In addition, linear model is the best fit (63%) with a life-span equal or slightly longer than In-ox. Linear model is the best fit (100%) with In-ox and the multiple hit analysis also showed significantly higher number of hits (34) compared to In-tr (15). There is no correlation between in vivo recovery of /sup 111/In-platelets (tropolone or oxine) and the platelet life span. These results show that even though the platelet life span is not significantly altered by labeling method, they are better preserved in circulation when labeled with In-tr.
- Research Organization:
- Mt. Sinai Medical Center, New York, NY
- OSTI ID:
- 6760985
- Report Number(s):
- CONF-850611-; TRN: 87-010619
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD PLATELETS
LABELLING
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
RETENTION FUNCTIONS
BIOLOGICAL HALF-LIFE
CHEMICAL REACTION KINETICS
CORRELATIONS
EVALUATION
INDIUM 111
LIVER
RADIONUCLIDE KINETICS
SPLEEN
TISSUE DISTRIBUTION
UPTAKE
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
GLANDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
REACTION KINETICS
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics