Comparison of oxine and tropolone methods for labeling human platelets with indium-111

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5894059

Kotze, H F; Heyns, A D; Loetter, M G.P.; Pieters, H; Roodt, J P; Sweetlove, M A; Badenhorst, P N ^[1]

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1. Univ. of the Orange Free State, Bloemfontein (South Africa)

The effect of the chelates oxine and tropolone, used to label platelets, on the kinetics of indium-111-({sup 111}In) labeled platelets was studied in twelve normal human subjects. Autologous platelets were labeled either in saline with {sup 111}In-oxine or in plasma with {sup 111}In-tropolone. Mean platelet lifespan was estimated by fitting the disappearance curve of platelets from the circulation to the multiple hit and other mathematical models. The in vivo distribution of platelets was quantitatively imaged with a scintillation camera. The in vivo recovery of {sup 111}In-oxine and {sup 111}In-tropolone did not differ, and the mean platelet lifespan was also similar ({sup 111}In-oxine: 230 +/- 29 hr; {sup 111}In-tropolone: 226 +/- 13 hr). At equilibrium (90 min after reinjection of labeled platelets) and at the end of platelet lifespan, {sup 111}In-oxine and {sup 111}In-tropolone radioactivities in the spleen and liver were similar. These results demonstrate that the results of kinetics measured with {sup 111}In-oxine or {sup 111}In-tropolone do not differ significantly.

• OSTI ID: 5894059
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:1; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CHELATING AGENTS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIFE SPAN
MAMMALS
MAN
MATERIALS
MATHEMATICAL MODELS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PRIMATES
PYRIDINES
QUINOLINES
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTILLATION COUNTING
VERTEBRATES