Fatty acid derivatives. omega. -substituted with a neutral technetium complex

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760322

Davison, A; Jones, A G; Lister-James, J; Costello, C E

The clinical importance of noninvasive probes of myocardial metabolism continues to promote investigation into the preparation of radiolabeled fatty acid derivatives useful for diagnostic imaging. The preparation of such compounds labeled with Tc-99m remains a major goal. Based on previous investigations of oxotechnetium(+5) bisamido bisthiolato (N/sub 2/S/sub 2/) complexes, the authors now report the synthesis of a series of ligands designed to form stable neutral technetium complexes whilst retaining the essential characteristics of a fatty acid. The design allows both for the incorporation of diverse fatty acid fragments and for metabolism of these fragments to produce a small readily excretable technetium complex as the final labeled metabolite. The first of these ligands, N,N'-ethylenebis-(2-mercapto)(2'-(11-carboxyundecyl)thio)acetamide, undergoes ligand exchange with Tc-99-(TcO(ethanediolato)2)/sup -/ to form a stable neutral lipophilic oxotechnetium(+5) complex as a diastereomeric pair of enantiomers. One pair of enantiomers has been characterized by elemental analysis, by its /sup 1/H and /sup 13/C NMR, IR, and UV spectra, and by fast-atom bombardment spectrometry. All data are consistent with the formulation: oxo(N,N'-ethylenebis- (2-mercapto)(2'-(11-carboxyundecyl)thio)acetamido)-technetium(+5). This complex can also be prepared at the tracer level by ligand exchange with Tc-99m-glucoheptonate. The Tc-99 and Tc-99m complexes co-elute on reverse-phase HPLC.

• Research Organization: Massachusetts Institute of Technology, Cambridge, MA
• OSTI ID: 6760322
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CARBOXYLIC ACIDS
CARDIOGRAPHY
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRUGS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGANDS
MEDICINE
METABOLISM
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NMR IMAGING
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
SCINTISCANNING
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
USES
YEARS LIVING RADIOISOTOPES