Preparation and characterization of two complexes of technetium with 2-mercaptocarboxylic acids

Journal Article · Mon Jun 01 04:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:5504664

Livni, E; Davis, M A; Warner, V D

We have synthesized the tetraphenylarsonium salts of oxotechnetium(V)bis-(2-mercaptopropionate) and oxotechnetium(V)bis-(2-mercaptohexadecanoate) containing macromolar quantities of the long-lived isotope technetium-99. The compounds were investigated by elemental analysis, paper electrophoresis, and infrared and ultraviolet-visual spectroscopy, proton nuclear magnetic resonance, and field-desorption mass spectrometry. The findings suggest that the technetium atom is coordinated by two sulfur and three oxygen atoms in a square pyramid, the two sulfur atoms and two of the oxygen atoms forming the base and the third oxygen atom the apex. The carboxyl oxygen coordinated to technetium will not be available for binding in vivo. This factor should be considered in the design of technetium 99m-labeled radiopharmaceuticals containing a mercapto group alpha to a carboxyl group.

• OSTI ID: 5504664
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
COMPLEXES
COORDINATION NUMBER
CRYSTAL LATTICES
CRYSTAL STRUCTURE
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOPHARMACEUTICALS
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
YEARS LIVING RADIOISOTOPES