Production of 7. 6-minute potassium-38 for medical use
A method is described for generating 20 to 30 mCi of 7.6-min potassium-38 by means of a small cyclotron. Sodium chloride is mounted on a water-cooled tantalum plate, by evaporation from an aqueous solution. It is bombarded with 14.7-MeV helium-4 ions, at 50 ..mu..A. The K-38 is produced free of other radionuclides. For intravenous injection the bombarded NaCl is dissolved in sufficient pyrogen-free water to make an isotonic saline solution, which then is sterilized by filtration. Other methods of production investigated were the bombardment of: carbon tetrachloride with He-4 ions; calcium oxide with 7.8-MeV deuterons; and potassium chloride with 23-MeV He-3 ions. These gave products that were unsuitable for clinical applications. Chiefly because of the short half-life of K-38, the whole-body radiation exposure is estimated to be only about 12 mrad/mCi, and exposures to the heart and kidneys are approximately ten times greater.
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 6760302
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
BEAMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BODY
CALCIUM COMPOUNDS
CALCIUM OXIDES
CARBON TETRACHLORIDE
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CHEMICAL PREPARATION
CHLORIDES
CHLORINATED ALIPHATIC HYDROCARBONS
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
CYCLIC ACCELERATORS
CYCLOTRONS
DOSES
DRUGS
HALIDES
HALOGEN COMPOUNDS
HALOGENATED ALIPHATIC HYDROCARBONS
HEART
HELIUM 3 BEAMS
HELIUM 4 BEAMS
ION BEAMS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POTASSIUM 38
POTASSIUM CHLORIDES
POTASSIUM COMPOUNDS
POTASSIUM ISOTOPES
PRODUCTION
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SECONDS LIVING RADIOISOTOPES
SODIUM CHLORIDES
SODIUM COMPOUNDS
SYNTHESIS