Observations of the dynamics of ionic potassium-38 in brain
Short time course potassium dynamics in brain were investigated in the cat. /sup 38/K (T1/2 . 7.6m) was prepared on the BNL 60'' cyclotron by the /sup 40/Ar(p, 3n)/sup 38/K reaction. Positron decay in brain was measured by the limited angle of view positron camera (LAPC). Radioactivity corrected for physical decay following intravenous bolus injection of /sup 38/K showed an initial peak followed by a washout phase with a subsequent monotonic increase. The slope of the washout phase was linearly related to PaCO2 and the subsequent monotonic increase paralleled the arterial concentration of the tracer. No significant changes in /sup 38/K radioactivity were determined following coma producing levels of phenobarbital or seizure producing doses of potassium penicillin as compared to control.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 7012932
- Journal Information:
- Stroke; (United States), Journal Name: Stroke; (United States) Vol. 15:1; ISSN SJCCA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AZINES
BARBITURATES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGY
BODY
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENOBARBITAL
POTASSIUM 38
POTASSIUM ISOTOPES
PYRIMIDINES
RADIOBIOLOGY
RADIOISOTOPES
RADIONUCLIDE KINETICS
SECONDS LIVING RADIOISOTOPES
VERTEBRATES