Xe-133 retention ratio: A useful index for fatty liver quantification

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760235

Yeh, S H; Wu, L C; Wang, S J; Lin, H C; Lee, S D; Wu, J C; Liu, R S

This study was undertaken to develop an index, Xe-133 retention ratio, useful for quantitating fatty liver (FL). Data were acquired in frame mode in the hepatic region and both lung bases for 5 min after rebreathing 20 mCi of gaseous Xe-133 and for another 5 min during washout. Static Tc-99m sulfur colloid liver imaging was performed with the patient in the identical position immediately after the ventilation study and data were stored for liver localization. A hepatic time-activity curve corrected for background activity was generated. The Xe-133 retention ratio (RR) was derived by dividing the activity at 3.5 min after washout by the peak activity. Sixteen normal subjects (N) and 15 patients (pts) with proved FL were studied. RRR (mean +- SD) was greatly increased in pts with FL (0.38 +- 0.20 vs 0.04 +- 0.08 in N, p < 0.005). The sensitivity and specificity for diagnosing FL were 0.93 and 0.94, respectively. There was a strong positive correlation between RR's and percentage of fat on biopsy (r = 0.92, SEE = 0.08, p < 0.005) in 15 pts. Intra-and interobserver variations for RR procedure were very small (r = 0.98 by each of 3 observers; r = 0.97, 0.98, 0.98 for interobserver correlation). The authors' preliminary results indicate that Xe-133 retention ratio provides a simple, accurate, and useful index of quantifying and evaluating fatty infiltration of the liver.

• Research Organization: Veterans General Hospital, Taipei
• OSTI ID: 6760235
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADIPOSE TISSUE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CHEMICAL ANALYSIS
COLLOIDS
CONNECTIVE TISSUE
CORRELATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIVER
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
RETENTION FUNCTIONS
SCINTISCANNING
SULFUR COMPOUNDS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRACER TECHNIQUES
UPTAKE
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES