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Tissue nonprotein sulfhydryl levels in rats following exposure to X irradiation

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
 [1];
  1. Medical College of Georgia, Augusta
+ Show Author Affiliations
The administration of glutathione and other nonprotein sulfhydryl (NPSH) compounds is known to increase the survival of animals receiving lethal doses of ionizing radiation. Little information is available concerning the effects of radiation on the tissue levels of NPSH compounds. In this study, the tissue nonprotein sulfhydryl concentration was determined in various organs of the rat during the early postirradiation period. Animals were sacrificed at 15 min; 4, 12, and 24 h; and 5 and 21 days following 650 R of X irradiation. Livers, spleens, and kidneys were rapidly removed and NPSH levels were determined. In the spleen there was significant increase in NPSH concentration occurring as early as 15 min after exposure. It returned to control levels at 4 h, but increased again at 24 h. At 24 h levels decresed sharply and remained depressed throughout the remainder of the observation period. In the liver a significant decrease occurred at 5 days.
OSTI ID:
6759764
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 165:2; ISSN PSEBA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
GLUTATHIONE
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
LETHAL IRRADIATION
LIVER
MAMMALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
THIOLS
TIME DEPENDENCE
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
X RADIATION