Apparatus for monitoring the oxygen uptake and carbon dioxide production of fermentations

Journal Article · Sat Jan 01 04:00:00 EST 1966 · Biotechnol. Bioeng.; (United States)

DOI:https://doi.org/10.1002/bit.260080407· OSTI ID:6759238

Jensen, A L; Schultz, J S

The requirements for the continuous analysis of effluent gas streams from aerated flask and tank fermentors are described, as are instrumental devices for measuring the oxygen and carbon dioxide content of fermentor gases. The use of a specially designed sequential gas sampler for monitoring four fermentations simultaneously and a system for precise control of low air flow and pressure is explained. Equations for calculating carbon dioxide production or oxygen consumption rates and respiratory quotients are given. A discussion of the operating characteristics of a device for automatic translation of aeration data between fermentors is presented. The frequency response for the oxygen control system with Streptomyces aureofaciens and Bacillus megaterium fermentations were measured to determine is the frequency response was sufficient for situations normally encountered in scale-up.

• Research Organization: American Cyanamid Co., Pearl River, NY
• OSTI ID: 6759238
• Journal Information: Biotechnol. Bioeng.; (United States), Journal Name: Biotechnol. Bioeng.; (United States) Vol. 8; ISSN BIBIA
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
AERATION
ATMOSPHERES
BACILLUS
BACILLUS MEGATERIUM
BACTERIA
BIOCONVERSION
BIOSYNTHESIS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CONTROLLED ATMOSPHERES
DESIGN
ELEMENTS
FERMENTATION
MEASURING INSTRUMENTS
MICROORGANISMS
MONITORING
NONMETALS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
STREPTOMYCES
SYNTHESIS
UPTAKE