Macrocyclic lactones: A versatile source for omega radiohalogenated fatty acid analogs
For each omega halogenated fatty acid there exists a potential omega hydroxy fatty acid and the corresponding macrocyclic lactone. The authors have utilized such lactones as starting materials for omega /sup 123/I fatty acid analogs intended for myocardial imaging. Macrocyclic musk lactones are industrially available; 120 analogs are described in the literature. The preparation requires saponification, tosylation, and radio-iodide substitution. Iodo-fatty acids are readily separated from tosylate fatty acids on TLC. While providing a secure source of 16-iodo-hexadecanoic acid and 17-iodo-heptadecanoic acid, the scheme allows ready access to a large number of untried fatty acid analogs. Examples presented are 16-iodo-hexadecanoic acid, 16-iodo-7-hexadecanoic acid, 16-iodo-12-oxa-hexadecanoic acid, 15-iodo-pentadecanoic acid, and 15-iodo-12-keto-pentadecanoic acid. Metabolic studies are in progress in mice and dogs to assess the utility of these analogs for myocardial imaging.
- Research Organization:
- TRIUMF and Univ. of British Columbia, Vancouver, BC
- OSTI ID:
- 6759088
- Report Number(s):
- CONF-840619-; TRN: 87-010791
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
IODINE 123
RADIOCHEMISTRY
LACTONES
HALOGENATION
MONOCARBOXYLIC ACIDS
CHEMICAL PREPARATION
LABELLING
MYOCARDIUM
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
DIAGNOSTIC USES
DOGS
HEXADECANOIC ACID
IMAGE PROCESSING
METABOLISM
MICE
SAPONIFICATION
STRUCTURE-ACTIVITY RELATIONSHIPS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
CHEMISTRY
COUNTING TECHNIQUES
DECOMPOSITION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HEART
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROLYSIS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LYSIS
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPES
RODENTS
SOLVOLYSIS
SYNTHESIS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation