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Siderophore-mediated mechanism of gallium uptake demonstrated in the microorganism Ustilago sphaerogena

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6758778
The radioactive gallium analog of ferrichrome, Ga-67 deferriferrichrome, has been prepared and compared with ferrichrome in the specific siderophore-transport system of Ustilago sphaerogena. The gallium analog is taken up by the cells in an active transport process indistinguishable from that of ferrichrome. The findings may explain how Ga(III) mimics Fe(III) in clinical use.
OSTI ID:
6758778
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 21:10
Country of Publication:
United States
Language:
English