Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · Am. J. Physiol.; (United States)

OSTI ID:6758371

Gutkind, J S; Kurihara, M; Saavedra, J M

We analyzed angiotensin II (ANG II) receptors by in vitro autoradiography in selective brain nuclei of control, salt-treated (1% NaCl in drinking water), deoxycorticosterone acetate (DOCA)-treated (DOCA pivalate, 25 mg/kg sc weekly), and DOCA-salt-treated (DOCA + salt treatments) uninephrectomized male Wistar-Kyoto rats. After 4 wk of treatment, only the DOCA-salt group developed hypertension. ANG II binding increased in median preoptic nucleus and subfornical organ of salt- and DOCA-treated rats. DOCA-treated rats also showed increased ANG II binding in paraventricular nucleus. DOCA-salt-treated rats showed higher ANG II binding in nucleus of the solitary tract and area postrema, as well as in the areas mentioned before. Although salt and/or DOCA treatments alone increased ANG II receptors in some brain nuclei, after combined DOCA-salt treatment there was significantly higher ANG II binding in all areas, except the median preoptic nucleus. These results suggest that increased ANG II receptors in selected brain areas may play a role in the pathophysiology of mineralocorticoid-salt experimental hypertension.

• Research Organization: National Institute of Mental Health, Bethesda, MD (USA)
• OSTI ID: 6758371
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 255; ISSN AJPHA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
ANIMALS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
BLOOD PRESSURE
BODY
BRAIN
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CELL CONSTITUENTS
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
DISEASES
DRUGS
GLOBULINS
HYPERTENSION
KINETICS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROTEINS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VASOCONSTRICTORS
VERTEBRATES