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Effects of chronic isoproterenol administration of. beta. /sub 1/-adrenoceptors and growth of pancreas of young and adult rats

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
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(/sup 3/H)Dihydroalprenolol (DHA) binding of membranes of adult pancreas differed from that of pancreas of young rats, and the DHA binding in the presence of atenolol or butoxamine also was different in the two age groups. The adult pancreas had 93% ..beta../sub 2/- and 7% ..beta../sub 1/-adrenoceptors and did not exhibit an increased incorporation of (/sup 3/H)thymidine into deoxyribonucleic acid (DNA) following 2 days of DL-isoproterenol (ISO) administration; in contrast, pancreas of the 20-day-old rat had 71% ..beta../sub 2/-adrenoceptors and 27% ..beta../sub 1/-adrenoceptors and exhibited a 34-fold increase over that of adult, and a 6-fold increase over that of the control 20-day-old pancreas. Acinar cell differentiation was also accelerated by a 7-day regimen of ISO administration from 13 to 20 days of age. These growth responses to ISO appear to be ..beta../sub 1/ mediated. The lack of ..beta../sub 1/-adrenoceptors in the adult may account for the failure of the adult pancreas to exhibit a growth response to ISO.

Research Organization:
Univ. of Alabama, Birmingham (USA)
OSTI ID:
6758199
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 188:2; ISSN PSEBA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BIOLOGICAL EFFECTS
BODY
CELL DIFFERENTIATION
CHRONIC INTAKE
DIGESTIVE SYSTEM
DNA
DRUGS
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PROTEINS
PYRIMIDINES
RATS
RECEPTORS
RIBOSIDES
RODENTS
SYMPATHOLYTICS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES