Schilling evaluation of pernicious anemia: current status
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:6757006
The Schilling examination remains a popular means of evaluating in vivo absorption of vitamin B/sub 12/. When absorption is abnormally low, the test may be repeated with addition to exogenous intrinsic factor (IF) in order to correct the IF deficiency that characterizes pernicious anemia. A dual-isotope variation provides a means of performing both stages of the test simultaneously, thereby speeding up the test and reducing dependence on complete urine collection. In vivo studies indicate that, when administered simultaneously, the absorption of unbound B/sub 12/ is elevated, and IF-bound B/sub 12/ is reduced, in pernicious-anemia patients, relative to the classic two-stage examination. A number of clinical studies indicate significant difficulty in resolving clincial diagnoses with the dual-tracer test. An algorithm is offered for selecting the most suitable variation of the Schilling test to improve the accuracy of test results and the ease of performance.
- Research Organization:
- Albert Einstein Coll. of Medicine, Bronx, NY
- OSTI ID:
- 6757006
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Reliability of the dual-isotope Schilling test for the diagnosis of pernicious anemia or malabsorption syndrome
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Journal Article
·
Fri May 01 00:00:00 EDT 1981
· Am. J. Clin. Pathol.; (United States)
·
OSTI ID:5706568
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Journal Article
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Fri Jan 13 23:00:00 EST 1961
· Canadian Medical Association Journal (Canada)
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OSTI ID:4106946
Dual isotope Schilling test for measuring absorption of food-bound and free vitamin B12 simultaneously
Journal Article
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Sat Oct 01 00:00:00 EDT 1983
· Am. J. Clin. Pathol.; (United States)
·
OSTI ID:7133750
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ALGORITHMS
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
COBALT 57
COBALT 58
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATHEMATICAL LOGIC
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PATIENTS
RADIOASSAY
RADIOISOTOPES
SYMPTOMS
VITAMIN B GROUP
VITAMIN B-12
VITAMINS
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ALGORITHMS
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
COBALT 57
COBALT 58
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATHEMATICAL LOGIC
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PATIENTS
RADIOASSAY
RADIOISOTOPES
SYMPTOMS
VITAMIN B GROUP
VITAMIN B-12
VITAMINS