Vincristine alters myoelectric activity and transit of the small intestine in rats

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Gastroenterology; (United States)

OSTI ID:6756777

Sninsky, C A

We investigated the motility of the small intestine in unanesthetized rats receiving vincristine (0.075, 0.50, 0.75 mg/kg i.v.). Motility was determined by two methods: myoelectric activity was monitored with indwelling bipolar electrodes, and intestinal transit was measured by the movement of radiochromium (Na/sup 51/CrO/sub 4/). Only the animals injected with the two higher doses had two distinct patterns of altered intestinal myoelectric activity within 2 h of drug administration. The first alteration occurred 44 +/- 6 min after vincristine administration and consisted of a marked increase in action potential activity with disruption of the migrating myoelectric complex. The second alteration consisted of a reappearance of the activity front of the migrating myoelectric complex with a significantly shorter periodicity. A marked reduction in spike activity occurred 3 days after vincristine injection in 3 of 10 animals receiving vincristine. A biphasic response was noted in intestinal transit. Disrupted activity front formation was associated with a significant delay in small bowel transit. In contrast, frequent activity front formation in rats was associated with significantly hastened transit. In summary, vincristine administration induces alterations of myoelectric activity of the small intestine in fasted rats and is associated with changes in intestinal transit.

• Research Organization: Veterans Administration Medical Center, Gainesville, FL
• OSTI ID: 6756777
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 2; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CHROMIUM 51
CHROMIUM ISOTOPES
CONTRACTION
DIGESTIVE SYSTEM
DRUGS
ELECTRODES
ELECTRON CAPTURE RADIOISOTOPES
ELECTROPHYSIOLOGY
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ORGANS
PHYSIOLOGY
RADIOISOTOPES
RATS
RODENTS
SMALL INTESTINE
TRACER TECHNIQUES
VERTEBRATES