Quantitative scintigraphy: Relation to unperfused volume at necropsy, immediately and 1 week after coronary occlusion

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6756732

Goodenday, L S; Wilkerson, R D; Leighton, R F; Muswick, G J; Hire, N E; Nelson, A D; Brewster, P; Yasnoff, W A

Interventions such as thrombolytic therapy, designed to preserve jeopardized myocardium after coronary thrombosis, suffer from inadequate scientific validation because of present limitations in the ability to measure the cardiac volume at risk initially, or to predict the eventual volume of unperfused tissue in the absence of intervention. To determine whether the unimpeded change in perfused myocardial volume over time could be predicted accurately in vivo, Tl-201 quantitative scintigraphy was performed in 10 dogs at 5 minutes and at 1 week after closed-chest coronary artery occlusion (CAO). Initial and final ischemic cardiac volumes (ICV) were measured at necropsy by autoradiography: Initial ICV from Ce-141 microspheres injected into the left ventricle 5 minutes after CAO and final ICV from autoradiography of Tl-201 given 1 week after CAO. Planar scintigrams were computer-analyzed with a quantitative anatomically-referenced technique. Early scintigraphic perfusion defect (SPD) size was closely related to initial ICV measured at necropsy, r=.93. SPD size decreased predictably by 50% during 1 week. Late SPD size correlated with final ICV at necropsy, r=.92. Size of the SPD 5 minutes after CAO predicted both size of the SPD 1 week later, r=.87, and also final ICV, r=.92. These data demonstrate that: 1) after acute canine CAO without therapeutic intervention, SPD size becomes predictably smaller with time; 2) this change reflects a change in the volume of ischemic myocardium; 3) quantitative scintigraphy accurately predicts both early and late ischemic cardiac volume as confirmed at autopsy.

• Research Organization: Medical College of Ohio, Toledo, OH
• OSTI ID: 6756732
• Report Number(s): CONF-850611-; TRN: 87-011086
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
AUTORADIOGRAPHY
ISCHEMIA
SCINTISCANNING
THROMBOSIS
MYOCARDIUM
ANATOMY
DETECTION
DOGS
RADIOPHARMACEUTICALS
THALLIUM 201
THERAPY
TISSUE DISTRIBUTION
UPTAKE
VALIDATION
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
TESTING
THALLIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
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