Extracorporeal irradiation of blood in goats with fully portable irradiators

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Radiat. Res.; (United States)

OSTI ID:6754797

Hungate, F P; Bunnell, L R; Riemath, W F; Karagianes, M T

A fully portable vitreous carbon-/sup 170/Tm blood irradiator in a carotid-jugular shunt reduces lymphocyte levels in goats, with recovery to preirradiation levels requiring several months. It appears that lymphocyte response to chronic irradiation is more closely related to daily cumulative dose than to acute dose (transit dose) delivered to blood during a single pass through the irradiator. Testing of different dose regimens is proceeding along with design changes being made to facilitate ultimate clinical evaluation. Umits now being tested utilize pristine vitreous carbon as the blood interface and isotope containment material. Scanning electron microscopy shows that material to be extremely smooth and initial testing in arteriovenous shunts indicates it is nonthrombogenic. Results of animal experiments now in progress will be presented in terms of lymphocytopenia induction and changes in cellular immune response; this will be compared with data published by others using intermittemt acute exposures achieved with nonportable extracorporeal blood irradiator equipment.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 6754797
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 62; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBON
CHRONIC EXPOSURE
CHRONIC IRRADIATION
CONNECTIVE TISSUE CELLS
DISEASES
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
ELEMENTS
GOATS
HEMIC DISEASES
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOTOPES
LEUKOCYTES
LEUKOPENIA
LYMPHOCYTES
LYMPHOPENIA
MAMMALS
MICROSCOPY
NONMETALS
NUCLEI
ODD-ODD NUCLEI
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUMINANTS
SOMATIC CELLS
SYMPTOMS
THULIUM 170
THULIUM ISOTOPES
VERTEBRATES