THE COMBINED APPLICATION OF LYMPH DUCT DRAINAGE AND EXTRACORPOREAL IRRADIATION OF THE BLOOD IN THE STUDY OF LYMPHOPOIESIS
Extracorporeal irradiation of the blood was prolonged for as long as 38 hours. Red cells are injured by the radiation dose. Hemolysis may commence after 28 hours presumably due to the irradiation. Utilizing extracorporeal irradiation of the blood combined with thoracic duct cannulation, one can measure minima for net lymphocyte input into the peripheral blood from all sources other than the thoracic duct. An unusual and new pathologic picture of lymph nodes and spleen has been produced by extracorporeal irradiation of the blood. Heparin mobilization of a large pool of lymphocytes into the blood directly and via the thoracic duct must be considered in all studies utilizing heparin as an anticoagulant. The lymphocytosis produced by this mobilization is suppressed by concurrent extracorporeal irradiation. The apparent quantitative destruction of the lymphocytes by extracorporeal irradiation of the blood may permit studies of lymphocytic function hitherto not possible by direct experimentation. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y.
- DOE Contract Number:
- AT(30-2)-GEN-16
- NSA Number:
- NSA-17-002818
- OSTI ID:
- 4780108
- Report Number(s):
- BNL-6342
- Country of Publication:
- United States
- Language:
- English
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