Increased incorporation of adenosine into adenine nucleotide pools in serum-deprived mammalian cells
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The effects of serum deprivation on the incorporation of adenosine into the intracellular adenine nucleotide pools by several mammalian cell lines were studied. Cells arrested in the G/sub 1/ phase of the cell cycle showed increased incorporation of exogenous adenosine into their adenine nucleotide pools as compared with growing cells. This phenomenon is unexpected because salvage pathways from all other preformed nucleosides and bases as well as the de novo synthesis of adenine nucleotides is decreased after arrest of growth by serum deprivation. The incorporation of adenosine into adenine nucleotides may serve as an intracellular signal in the regulation of growth in mammalian cells.
- Research Organization:
- Harvard Univ., Boston
- OSTI ID:
- 6753607
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 75:3; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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