Clinical evaluation of a /sup 51/Cr-labeled red blood cell survival test for in vivo blood compatibility testing

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Mayo Clin., Proc.; (United States)

DOI:https://doi.org/10.1016/S0025-6196(12)60338-3· OSTI ID:6749505

Pineda, A A; Dharkar, D D; Wahner, H W

Modified red blood cell survival studies with use of 51Cr were performed in three groups of subjects. Group 1 consisted of normal subjects who were given labeled autologous blood, group 2 were subjects in need of blood transfusions and given labeled ABO and Rh crossmatch-compatible blood, and group 3 were patients in need of blood transfusion but in whom problems arose in finding compatible blood. The results of the studies suggest that for patients with blood compatibility problems, normal red blood cell survival values at 1 hour do not exclude the possibility of severe hemolysis 24 hours later. Thus, if a 1-hour test result is normal, the procedure should be extended routinely to 24 hours. Moreover, the test can be used to evaluate the clinical importance of antibodies. We showed that anti-Yka and anti-Lan were clinically significant, but high-titer, low-avidity antibodies, anti-Kna, anti-I, and anti-HI were clinically insignificant in the cases studied. This finding emphasizes the importance of an in vivo test for the final compatibility evaluation in complicated blood replacement problems.

• Research Organization: Mayo Graduate School of Medicine, Rochester, MN
• OSTI ID: 6749505
• Journal Information: Mayo Clin., Proc.; (United States), Journal Name: Mayo Clin., Proc.; (United States) Vol. 59:1; ISSN MACPA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD GROUPS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
COMPATIBILITY
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
HEMOLYSIS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LYSIS
MAMMALS
MAN
MATERIALS
NUCLEI
PATHOLOGICAL CHANGES
PRIMATES
RADIOISOTOPES
SURVIVAL TIME
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS
VERTEBRATES