Enhanced killing of human small cell lung cancer by hyperthermia and indium-111-bleomycin complex

Journal Article · Tue May 01 04:00:00 EDT 1990 · Journal of Surgical Oncology; (USA)

DOI:https://doi.org/10.1002/jso.2930440103· OSTI ID:6749160

Hou, D Y; Maruyama, Y ^[1]

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1. Univ. of Kentucky Medical Center, Lexington (USA)

Indium-111-bleomycin complex ({sup 111}In-BLMC) is a radiopharmaceutical agent that produces tumor regression in mouse glioma in vivo and kills human small cell lung cancer (SCLC) cells in vitro. The interaction between hyperthermia and {sup 111}In-BLMC against human SCLC (N417) cells was studied for bleomycin (BLM) (15 micrograms/ml) or {sup 111}In-BLMC (40-50 microCi carried by 15 micrograms BLM/ml) for 5 min or 1.5, 2, or 4 hr at 37{degrees}C or 43{degrees}C exposures. Cell survival was determined by colony formation in soft agarose. There was a synergistic effect for {sup 111}In-BLMC and hyperthermia for cell killing. At 37{degrees}C, the percent survival of N417 cells for BLM alone was 25.9%, and for {sup 111}In-BLMC it was 13.2%; at 43 degrees C, survival was 5.3% for BLM alone and 1.2% for {sup 111}In-BLMC by a 4 hr treatment. Effectiveness was greater when {sup 111}In-BLMC was combined with hyperthermia.

• OSTI ID: 6749160
• Journal Information: Journal of Surgical Oncology; (USA), Journal Name: Journal of Surgical Oncology; (USA) Vol. 44:1; ISSN JSONA; ISSN 0022-4790
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BLEOMYCIN
BODY
BODY TEMPERATURE
CELL KILLING
COLONY FORMATION
COMBINED THERAPY
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HYPERTHERMIA
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MAN
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM
SURVIVAL TIME
THERAPY
TUMOR CELLS
VERTEBRATES