Interstitial radiotherapy for the treatment of advanced or recurrent vulvar and distal vaginal malignancy

Journal Article · Tue May 01 04:00:00 EDT 1990 · American Journal of Obstetrics and Gynecology; (USA)

DOI:https://doi.org/10.1016/0002-9378(90)90036-7· OSTI ID:6749158

Hoffman, M; Greenberg, S; Greenberg, H; Fiorica, J V; Roberts, W S; LaPolla, J P; Noriega, B K; Cavanagh, D ^[1]

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1. Univ. of South Florida College of Medicine, Tampa (USA)

From March 1, 1985 to April 30, 1988 10 patients with locally advanced primary or recurrent vulvar or distal vaginal malignancy were managed with interstitial radiotherapy with or without teletherapy. One patient died of complications of a total pelvic exenteration for radionecrosis 8 months after completion of radiotherapy. The remaining nine patients were alive at a mean follow-up of 28 months (14 to 50 months). Recurrent disease developed within a bed of severe radionecrosis in two patients at 13 and 47 months after completion of radiotherapy. The remaining seven patients have remained without evidence of recurrent disease. Of the 10 total patients severe radionecrosis developed in six at a median of 8.5 months (6 to 26 months) after radiotherapy. We conclude from our data that the use of interstitial needles, mainly combined with external radiotherapy, for the treatment of locally advanced primary or recurrent vulvar and introital malignancy is highly effective but also highly morbid.

• OSTI ID: 6749158
• Journal Information: American Journal of Obstetrics and Gynecology; (USA), Journal Name: American Journal of Obstetrics and Gynecology; (USA) Vol. 162:5; ISSN AJOGA; ISSN 0002-9378
• Country of Publication: United States
• Language: English

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560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
FEMALE GENITALS
INJURIES
MAMMALS
MAN
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
VERTEBRATES