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Effect of cystamine on protein, phospholipid and RNA synthesis or degradation

Journal Article · · Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:6748169
; ;
Cystamine administration to rats partially inhibited (14C)-leucine incorporation to microsomal proteins, and (14C) orotic acid incorporation to RNA but markedly stimulated (32P) incorporation to liver microsomal phospholipids. Cystamine administration did not modify the decay of radioactivity of liver microsomal lipids prelabeled with (32P) or of microsomal protein prelabeled with ((14C)-guanidino)arginine. Notwithstanding cystamine increased the RNA content in total liver. Results suggest that cystamine inhibits protein synthesis, stimulates phospholipid synthesis and inhibits RNA synthesis and degradation.
Research Organization:
Centro de Investigaciones Toxicologicas, CITEFA/CONICET, Buenos Aires, Republica Argentina
OSTI ID:
6748169
Journal Information:
Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 43:3; ISSN RCOCB
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CYSTAMINE
DAYS LIVING RADIOISOTOPES
DRUGS
ESTERS
ISOTOPES
LABELLED COMPOUNDS
LEUCINE
LIGHT NUCLEI
LIPIDS
MAMMALS
MICROSOMES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
PHOSPHOLIPIDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RATS
RNA
RODENTS
SYNTHESIS
UPTAKE
VERTEBRATES