Cardiovascular effects of isoproterenol in the preterm newborn lamb

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Crit. Care Med.; (United States)

DOI:https://doi.org/10.1097/00003246-198401000-00009· OSTI ID:6746904

Crone, R K

A study was made of the effects of an isoproterenol infusion on cardiac output and the distribution of blood flow in 5 preterm newborn lambs. Cardiac output and regional organ blood flow were measured by injecting radionuclide-labeled microspheres into the superior vena cava and left ventricle. We found that an average infusion of 0.5 microgram/kg X min of isoproterenol increased cardiac output 73% which correlated closely with an increase in stroke volume, but not with HR. The increase in systemic blood flow was distributed exclusively to the myocardium and skeletal muscle, bone, and skin. We conclude that isoproterenol increases cardiac output in preterm newborn lambs similarly to adults and that the stroke volume of the immature heart is more changeable than previously thought.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 6746904
• Journal Information: Crit. Care Med.; (United States), Journal Name: Crit. Care Med.; (United States) Vol. 12:1; ISSN CCMDC
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DOMESTIC ANIMALS
DRUGS
HEART
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
MAMMALS
MEASURING METHODS
MICROSPHERES
NEONATES
ORGANS
RADIOISOTOPE SCANNING
RUMINANTS
SHEEP
STIMULATION
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES