Effects of isoproterenol on distribution of perfusion in embolized dog lungs

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5707053

Shepard, Jr, J W; Hauer, D; Sgroi, V; Moser, K M

In 19 mechanically ventilated, anesthetized dogs, autologous venous thrombi were formed in the inferior vena cava and subsequently released. Serial perfusion lung scintigrams revealed the postembolic distribution of pulmonary blood flow before, during, and after the infusion of isoproterenol at 2.2 ..mu..g/min. Isoproterenol failed to restore perfusion to embolically occluded regions. When reperfusion occurred it was attributable to clot resolution. Gas exchange and hemodynamic measurements obtained in seven thromboembolized animals showed no scan evidence of reperfusion during the isoproterenol infusion. After embolization, cardiac output increased from 1.7 to 2.6 liter/min (p < 0.05), and P anti ..nu..O/sub 2/ from 38.0 to 45.3 mm Hg (p < 0.05). Shunt fraction remained unchanged. The postembolic infusion of isoproterenol was associated with a further increase in cardiac output to 3.6 liter/min (p < 0.01), an elevation in P anti ..nu..O/sub 2/ to 50.7 mm Hg, along with a decrease in pulmonary vascular resistance from the postembolic mean of 448 to 246 dynes.sec.cm/sup -5/ (p < 0.05). Perfusion defects following acute pulmonary thromboembolization are not altered by the infusion of the potent pulmonary vasodilator, isoproterenol. Infusion of this drug following thromboembolization may have potential therapeutic benefit by reducing pulmonary vascular resistance, increasing cardiac output, and elevating the mixed-venous oxygen tension.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 5707053
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
EMBOLI
EXPERIMENTAL DATA
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MICROSPHERES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PERFUSED TISSUES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SYMPATHOMIMETICS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
THROMBOSIS
TISSUES
VASODILATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES