Early cellular effects of circulating cadmium-thionein on kidney proximal tubules. [Rats]

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.7928287· OSTI ID:6746666

Squibb, K S; Ridlington, J W; Carmichael, N G; Fowler, B A

Circulating cadmium-thionein (Cd-MT) is cleared from the mammalian circulatory system by filtration through the kidney glomerulus with subseqent reabsorption by kidney proximal tubules. Damage to the tubules results following uptake of Cd-MT, which is dependent upon time and the dose level of cadmium administered. Intravenous administration of /sup 109/Cd-MT at doses of 0.017 and 0.17 mg Cd/kg body weight disclosed that the rate of clearance from the blood and uptake by the kidney was significantly more rapid at the 0.017 mg Cd/kg dose. Ultrastructural changes were characterized by increased numbers of pinocytotic vesicles and small, dense lysosomal structures. There was no evidence of mitochondrial swelling or cell death at either 3 or 6 h after injection. Results suggest that Cd-MT is reabsorbed and broken down by kidney tubule cells in a physiological manner with possible subsequent release of the toxic cadmium ion.

• Research Organization: Univ. of North Carolina, Chapel Hill
• OSTI ID: 6746666
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 28; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
CELL CONSTITUENTS
CHEMICAL ANALYSIS
CLEARANCE
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LYSOSOMES
MAMMALS
METALS
MICROSCOPY
MITOCHONDRIA
MORPHOLOGICAL CHANGES
NONDESTRUCTIVE ANALYSIS
NUCLEI
ORGANOIDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
TIME DEPENDENCE
TUBULES
ULTRASTRUCTURAL CHANGES
UPTAKE
VERTEBRATES
X-RAY EMISSION ANALYSIS
YEARS LIVING RADIOISOTOPES